(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Names and Identifiers
Name | (S,R)-noscapine
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Synonyms | nsc5366 narcotine (S,R)-noscapine 1-alpha-Narcotine ,2,3,4-tetrahydroisoquinaline 5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4 5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4 6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one 6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one 6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]- (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride
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CAS | 128-62-1
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EINECS | 204-899-2 |
InChI | InChI=1/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18-;/m1./s1 |
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Physico-chemical Properties
Molecular Formula | C22H23NO7
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Molar Mass | 413.42 |
Density | 1.395 |
Melting Point | 174-176°C(lit.) |
Boling Point | 532.6°C (rough estimate) |
Specific Rotation(α) | -200 º (c=1 in chloroform) |
Flash Point | 308.5°C |
Water Solubility | 302.9mg/L(25 ºC) |
Solubility | Practically insoluble in water, soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in strong acids; on dilution of the solution with water, the base may be precipitated. |
Vapor Presure | 4.83E-14mmHg at 25°C |
Appearance | Crystalline solid |
Color | Orthorhombic prisms or stout needles from alc |
Merck | 13,6752 |
pKa | 7.8(at 25℃) |
Storage Condition | -20°C Freezer, Under Inert Atmosphere |
Refractive Index | 1.5614 (estimate) |
Physical and Chemical Properties | Colorless crystalline powder or glossy prismatic or flaky crystals; Odorless and tasteless. Almost insoluble in water, slightly soluble in ethanol and ether, soluble in chloroform. |
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Risk and Safety
Hazard Symbols | Xn - Harmful
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Risk Codes | 22 - Harmful if swallowed
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Safety Description | 24/25 - Avoid contact with skin and eyes.
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UN IDs | 1544 |
WGK Germany | 3 |
RTECS | RD2625000 |
HS Code | 29329990 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | cyt-ham:lng 100 mg/L ATSUDG (4),41,80 |
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Standard
Authoritative Data Verified Data
This product is (S-R 'S')]-6, 7-dimethoxy-3-(5,6, 7, 8-tetrahydro-6-methyl-4-methoxy-1, 3-dioxolene [4,5-g]-5-isoquinolyl)-1(3H)-isobenzofuranone. Calculated as dried product, the content of C22H23N07 shall not be less than 99.0%.
Last Update:2024-01-02 23:10:35
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Trait
Authoritative Data Verified Data
- This product is white crystalline powder or glossy prismatic crystal; Odorless.
- This product is soluble in chloroform, slightly soluble in ethanol or ether, and almost insoluble in water.
melting point
The melting point of this product (General 0612) is 174~177°C.
specific rotation
take this product, precision weighing, plus O. 1 mol/L hydrochloric acid solution was dissolved and quantitatively diluted to give a solution containing about 20mg per 1 ml, which was measured according to law (General 0621). The specific rotation was 42 ° to 48 °.
Last Update:2022-01-01 11:54:19
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Differential diagnosis
Authoritative Data Verified Data
- take about 1 mg of this product, add 1 drop of sulfuric acid to dissolve, into a yellow-green solution, warm red, and finally turned purple.
- take about 1 mg of this product, add 1 drop of molybdenum sulfuric acid test solution, show dark green, gradually change to purple after warming.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 609).
Last Update:2022-01-01 11:54:20
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Exam
Authoritative Data Verified Data
clarity and color of acetone solution
take 0.2g of this product, add acetone 10ml to dissolve, the solution should be clear and colorless; If the color is colored, compared with the yellow No. 2 Standard Colorimetric liquid (General rule 0901 first method), not deeper.
Related substances
take this product, add the mobile phase to dissolve and dilute to make a solution containing lmg per lml as a test solution; Take lml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the high performance liquid chromatography (General 0512) test, using eighteen alkyl silane bonded silica gel as filler; Methanol -0.lmol /L sodium dihydrogen phosphate solution (85:15) as mobile phase; The detection wavelength was 290nm. The number of the theoretical plates shall not be less than 2000 based on the calculation of the Ding peak. 20 u1 of test solution and 20 u1 of control solution were respectively injected into human liquid chromatograph, and the chromatogram was recorded to 2.5 times of the retention time of principal component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update:2022-01-01 11:54:21
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Content determination
Authoritative Data Verified Data
take about 0.3g of this product, precision weighing, add glacial acetic acid 10ml dissolved, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a clear blue color of the solution, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 41.34mg of C22H23NO7.
Last Update:2022-01-01 11:54:21
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Category
Authoritative Data Verified Data
Last Update:2022-01-01 11:54:21
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update:2022-01-01 11:54:21
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one - Natcodine tablets
Authoritative Data Verified Data
This product contains 93.0% ~ 107.0% of the label amount of nacrine (C22H23N07).
trait
This product is sugar-coated tablets, White after removing the coating.
identification
take an appropriate amount of fine powder of this product (about 20mg equivalent to that of nacrodine), add 10ml of chloroform, stir to dissolve nacrosine, filter, and evaporate the filtrate on a water bath, the residue showed the same reaction according to the test of identification (1) and (2) under the nacrine.
examination
- Content uniformity: Take 1 tablet of this product, grind it finely, add an appropriate amount of ethanol, grind it and transfer it to a 50ml measuring flask, fully shake it to dissolve the nacrine, then dilute it to the scale with ethanol, shake well, filter, Take 5ml of the filtrate accurately, put it in a 25ml measuring flask, dilute it with ethanol to the scale, shake well, and use it as a test solution, precision weighing, dissolved in ethanol and quantitatively diluted to make a solution containing 40ug per 1 ml, as a reference solution. According to UV-visible spectrophotometry (General rule 0401), measure the absorbance at the wavelength of 310mn respectively, calculate the content, should comply with the regulations (General rule 0941).
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 30 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (about equivalent to 0.lg), add chloroform 20ml, shake, dissolve nacropin, filter, wash the container and filter with chloroform for 8 times, 5ml each time, combine the wash solution and filtrate, add glacial acetic acid 10ml, crystal violet indicator solution 1 drop, titrated with perchloric acid titration solution (0.05mol/L) to a clear blue solution, and the titration results were corrected with a blank test. Per 1 ml of perchloric acid titration solution (0.05mol/L) corresponds to 20.67mg of C22H23N07.
category storage
same as that of Codin.
specification
lOmg
Last Update:2022-01-01 11:54:22